A Shiny app to run Grand Mean comparisons for Central Statistical Monitoring

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Central Statistical Monitoring (CSM) is gaining widespread recognition for its contribution to improving data integrity and regulatory compliance in clinical trials. While the existing literature offers numerous approaches based on fundamental statistical techniques, many of these methods exhibit notable limitations and shortcomings.

This web application introduces a flexible framework for implementing CSM by comparing the average values from individual centers to the overall Grand Mean (GM). The methodology is adaptable to diverse data types through suitable statistical modeling. Users can upload their datasets and perform these comparisons directly within the app.

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